Sex-specific Alzheimer’s treatment found to benefit males but not females

A University of Ottawa study has found a specific Alzheimer’s treatment is effective in male and not female mice, providing a window into the biology of the disease and the effectiveness of targeted treatments. The paper, ‘AB oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner,’ published in Science Signaling Magazine highlights the mechanisms underlying Alzheimer’s disease are fundamentally different between men and women in regards to one specific treatment. The study was led by first author Dr. Khaled Abdelrahman alongside senior author Dr. Stephen Ferguson, both of the Faculty of Medicine’s Department of Cellular and Molecular Medicine and the Brain and Mind Research Institute.